261. Directed Evolution of an Antibody-Evading Cardiac Tropic AAV Vector

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hicks Antibody for Smoking Cessation AAV - Directed Persistent Expression of a Gene Encoding Anti - Nicotine

this approach in clinical trials. mice in this study were not addicted to the drug. Successful results from such a test would then support investigating Further work will be needed to test this vector in a rodent model trained to self-administer nicotine, because the were abolished or greatly reduced in mice that expressed the anti-nicotine antibodies. antibodies. Furthermore, the usual nicotin...

متن کامل

[Directed evolution of antibody molecules in phage-displayed combinatorial libraries].

Advances in methods for conformational prediction, structural analysis and site-directed mutagenesis of proteins and peptides have contributed to the understanding of their structure and function. However, with the exception of a few successes, the generation of practical functional molecules solely by rational design remains a difficult challenge. The aim of our study is to investigate molecul...

متن کامل

Predicting cardiac arrhythmia on ECG signal using an ensemble of optimal multicore support vector machines

The use of artificial intelligence in the process of diagnosing heart disease has been considered by researchers for many years. In this paper, an efficient method for selecting appropriate features extracted from electrocardiogram (ECG) signals, based on a genetic algorithm for use in an ensemble multi-kernel support vector machine classifiers, each of which is based on an optimized genetic al...

متن کامل

Directed evolution of an RNA enzyme.

An in vitro evolution procedure was used to obtain RNA enzymes with a particular catalytic function. A population of 10(13) variants of the Tetrahymena ribozyme, a group I ribozyme that catalyzes sequence-specific cleavage of RNA via a phosphoester transfer mechanism, was generated. This enzyme has a limited ability to cleave DNA under conditions of high temperature or high MgCl2 concentration,...

متن کامل

Directed Evolution of an Artificial Cell Lineage

Biological development is a complex process that mediates between genotypes, to which mutations occur, and phenotypes, on which selection acts. Properties of development can therefore have considerable impact on evolution. However, in many existing simulation models of development, the developmental process itself is difficult to recover and/or analyse. We have previously introduced a model of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Molecular Therapy

سال: 2015

ISSN: 1525-0016

DOI: 10.1016/s1525-0016(16)33870-9